Pax6 transcription factor is required for the interkinetic nuclear movement of neuroepithelial cells

Hiroshi Tamai, Hiroshi Shinohara, Takaki Miyata, Kanako Saito, Yuji Nishizawa, Tadashi Nomura, Noriko Osumi

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

The mammalian cerebral cortex develops from proliferative neuroepithelial cells that exhibit a cell cycle-dependent nuclear movement (interkinetic nuclear migration; INM). Pax6 transcription factor plays pivotal roles in various aspects of corticogenesis. From live observation using cultured cortical slices from the Pax6 mutant rat, we identified the premature descent of S phase cells, the unsteady ascent or descent of G2 phase cells, and ectopic cell division within the basal side of the ventricular zone (VZ). The centrosome normally stayed at the most apical side, apart from the nucleus, in the neuroepithelial cell during the S to G2 phase, while the Pax6 mutant showed unstable movement of the centrosome associated with an abnormal INM. Our results suggest the possibility that Pax6 regulates the INM by stabilizing the centrosome at the apical side.

Original languageEnglish
Pages (from-to)983-996
Number of pages14
JournalGenes to Cells
Volume12
Issue number9
DOIs
Publication statusPublished - 2007 Sep 1

ASJC Scopus subject areas

  • Genetics
  • Cell Biology

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