TY - JOUR
T1 - Paucity of dendritic cells in pancreatic cancer
AU - Dallal, Ramsey M.
AU - Christakos, Peter
AU - Lee, Kenneth
AU - Egawa, Shinichi
AU - Son, Young Ik
AU - Lotze, Michael T.
N1 - Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2002
Y1 - 2002
N2 - Background. The number of dendritic cells (DC) in the local tumor environment correlates with patient survival in numerous tumors. The relationship of DC infiltration in the tumor microenvironment and prognosis was examined in patients with pancreatic adenocarcinoma. Methods. Forty-seven pancreatectomy specimens with a diagnosis of pancreatic adenocarcinoma were identified retrospectively and analyzed with the dendritic cell markers S-100 and CD1a. Patient survival was correlated with these markers and with p53, CD3, CD20, CD68, Ki-67. Results. Significant numbers (>3 per high-powered field) of tumor-associated S100+ or CDIa+ cells were found in only 2/4 7 patients (4%). When present, dendritic cells were located outside the margin of the tumor. CD3, CD68, and CD20 positive cells were rare or absent in 96%, 92%, and 93% of the specimens. A correlation with survival and numbers of immune cells could not be made secondary to their rarity. The median survival was 18.9 months. No other indices measured correlated with survival. Conclusions. In patients with pancreatic adenocarcinoma, there is a paucity of immune cells within the tumor.
AB - Background. The number of dendritic cells (DC) in the local tumor environment correlates with patient survival in numerous tumors. The relationship of DC infiltration in the tumor microenvironment and prognosis was examined in patients with pancreatic adenocarcinoma. Methods. Forty-seven pancreatectomy specimens with a diagnosis of pancreatic adenocarcinoma were identified retrospectively and analyzed with the dendritic cell markers S-100 and CD1a. Patient survival was correlated with these markers and with p53, CD3, CD20, CD68, Ki-67. Results. Significant numbers (>3 per high-powered field) of tumor-associated S100+ or CDIa+ cells were found in only 2/4 7 patients (4%). When present, dendritic cells were located outside the margin of the tumor. CD3, CD68, and CD20 positive cells were rare or absent in 96%, 92%, and 93% of the specimens. A correlation with survival and numbers of immune cells could not be made secondary to their rarity. The median survival was 18.9 months. No other indices measured correlated with survival. Conclusions. In patients with pancreatic adenocarcinoma, there is a paucity of immune cells within the tumor.
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U2 - 10.1067/msy.2002.119937
DO - 10.1067/msy.2002.119937
M3 - Article
C2 - 11854690
AN - SCOPUS:0036183808
VL - 131
SP - 135
EP - 138
JO - Surgery (United States)
JF - Surgery (United States)
SN - 0039-6060
IS - 2
ER -