Patterned differentiation of individual embryoid bodies in spatially organized 3D hybrid microgels

Hao Qi, Yanan Du, Lianyong Wang, Hirokazu Kaji, Hojae Bae, Ali Khademhosseini

Research output: Contribution to journalArticlepeer-review

88 Citations (Scopus)

Abstract

A microengineered hybrid hydrogel array is developed containing asymmetrical extracellular matrices [polyethylene-glycol (PEG) and gelatin methacrylate (GelMA)] to mimic the anisotropic stem cell niche and induce the patterned differentiation of embryoid bodies (EBs). The asymmetrical matrices around individual aggregate of mouse EBs induce polarity and demonstrate the potential of microscale engineered materials for forming tissues.

Original languageEnglish
Pages (from-to)5276-5281
Number of pages6
JournalAdvanced Materials
Volume22
Issue number46
DOIs
Publication statusPublished - 2010 Dec 7

Keywords

  • embryoid bodies
  • embryonic stem cells
  • hydrogels
  • microengineering
  • polarity

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

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