Patient-specific morphological and blood flow analysis of pulmonary artery in the case of severe deformations of the lung due to pneumothorax

Jean Joseph Christophe, Takuji Ishikawa, Noriaki Matsuki, Yohsuke Imai, Kei Takase, Marc Thiriet, Takami Yamaguchi

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Pneumothorax is characterized by lung collapse. Its effect on hemodynamics, especially on pulmonary arterial blood flow, remains unclear. This patient-specific study investigated the effects of lung deformation on pulmonary blood flow during acute phase and after recovery. Arterial geometry was extracted up to the fifth generation from computed tomography images in three patients and reconstructed. Different geometrical parameters (artery bores, area ratios, and between-branch angles) were computed. The shapes of the pulmonary trunk and its branches were affected strongly by pneumothorax. To clarify the effect of geometrical perturbations on blood flow, the Navier-Stokes equations for a steady laminar flow of Newtonian incompressible fluid were solved in a reconstructed domain. The change in flow structure between acute phase and recovery was associated with variations in flow rate ratio between the right and left lungs. This study shows, possibly for the first time, that from a patient-specific numerical test, pneumothorax has a considerable impact on pulmonary arterial morphology and hemodynamics.

Original languageEnglish
Pages (from-to)485-498
Number of pages14
JournalJournal of Biomechanical Science and Engineering
Volume5
Issue number5
DOIs
Publication statusPublished - 2010

Keywords

  • Computational fluid dynamics
  • Morphological analysis
  • Patient-specific model
  • Pneumothorax
  • Pulmonary arteries

ASJC Scopus subject areas

  • Biomedical Engineering

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