Abstract
In vitro aggregated single-chain Fv antibody (scFv) was analyzed by attenuated total reflectance Fourier transform infrared spectra and scanning electron microscope images. The spectroscopic results demonstrate that the formation of β-strands is a first trigger to the off-pathway toward insoluble aggregates, which is independent of redox condition; however, the morphology of the insoluble aggregates is strongly influenced by the environment in which scFv is aggregated.
Original language | English |
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Pages (from-to) | 1600-1601 |
Number of pages | 2 |
Journal | Chemistry Letters |
Volume | 33 |
Issue number | 12 |
DOIs | |
Publication status | Published - 2004 Dec 5 |
ASJC Scopus subject areas
- Chemistry(all)