Pathophysiological roles of ASK1-MAP kinase signaling pathways

Hiroaki Nagai; Takuya Noguchi; Kohsuke Takeda; Hidenori Ichijo

doi:10.5483/bmbrep.2007.40.1.001

Pathophysiological roles of ASK1-MAP kinase signaling pathways

Hiroaki Nagai, Takuya Noguchi, Kohsuke Takeda, Hidenori Ichijo

Research output: Contribution to journal › Review article › peer-review

188 Citations (Scopus)

Abstract

Apoptosis signal-regulating kinase 1 (ASK1) is a mitogen-activated protein kinase (MAPK) kinase kinase that activates JNK and p38 kinases. ASK1 is activated by various stresses, such as reactive oxygen species (ROS), endoplasmic reticulum (ER) stress, lipopolysaccharide (LPS) and calcium influx which are thought to be responsible for the pathogenesis or exacerbations of various human diseases. Recent studies revealed the involvement of ASK1 in ROS- or ER stress-related diseases, suggesting that ASK1 may be a potential therapeutic target of various human diseases. In this review, we focus on the current findings for the relationship between pathogenesis and ASK1-MAPK pathways.

Original language	English
Pages (from-to)	1-6
Number of pages	6
Journal	Journal of Biochemistry and Molecular Biology
Volume	40
Issue number	1
DOIs	https://doi.org/10.5483/bmbrep.2007.40.1.001
Publication status	Published - 2007 Jan
Externally published	Yes

Keywords

ASK1
ER stress
Innate immunity
MAPK
Oxidative stress

ASJC Scopus subject areas

Biochemistry
Molecular Biology

UN SDGs

This output contributes to the following Sustainable Development Goal(s)

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10.5483/bmbrep.2007.40.1.001

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AU - Nagai, Hiroaki

AU - Noguchi, Takuya

AU - Takeda, Kohsuke

AU - Ichijo, Hidenori

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Y1 - 2007/1

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AB - Apoptosis signal-regulating kinase 1 (ASK1) is a mitogen-activated protein kinase (MAPK) kinase kinase that activates JNK and p38 kinases. ASK1 is activated by various stresses, such as reactive oxygen species (ROS), endoplasmic reticulum (ER) stress, lipopolysaccharide (LPS) and calcium influx which are thought to be responsible for the pathogenesis or exacerbations of various human diseases. Recent studies revealed the involvement of ASK1 in ROS- or ER stress-related diseases, suggesting that ASK1 may be a potential therapeutic target of various human diseases. In this review, we focus on the current findings for the relationship between pathogenesis and ASK1-MAPK pathways.

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KW - Oxidative stress

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Pathophysiological roles of ASK1-MAP kinase signaling pathways

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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