Pathophysiologic role of histamine: Evidence clarified by histidine decarboxylase gene knockout mice

Hiroshi Ohtsu

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)

Abstract

The role of histamine in various murine disease models has been clarified using histidine decarboxylase gene knockout mice. The mice were generated using conventional gene-targeting methods. Studies, including ours, using knockout mice have shown that the activity of histamine is not limited to allergic, peptic and neurologic functions as in the old paradigm, but extends to other processes related to wound healing, circulatory disease, immunology, oncology and infectious disease. The recent observation of the activity of newly cloned histamine receptors and a pathophysiologic effect of histamine has dramatically expanded our understanding of the scope of histamine function.

Original languageEnglish
Pages (from-to)2-6
Number of pages5
JournalInternational archives of allergy and immunology
Volume158
Issue numberSUPPL. 1
DOIs
Publication statusPublished - 2012 May 1

Keywords

  • Histamine function
  • L-Histidine decarboxylase gene knockout mice
  • Wound healing

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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