Pathological study of subacute autoimmune encephalopathy with anti-AQP4 antibodies in a pregnant woman

Hiroaki Yaguchi, Ichiro Yabe, Yoshiki Takai, Tatsuro Misu, Masaaki Matsushima, Toshiyuki Takahashi, Kanako C. Kubota, Sachiko Akimoto, Kazuo Fujihara, Hidenao Sasaki

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

A pregnant woman with extensive brain lesions on magnetic resonance imaging was tested positive for anti-aquaporin4 (AQP4) antibodies. An open biopsy of the left temporal lobe showed pathological changes in both the white and gray matter. Hematoxylin and eosin, Klüver-Barrera, and myelin basic protein staining results were indicative of demyelination in the white matter. Loss of AQP4 and glial fibrillary acidic protein was observed in the white matter, and this finding is consistent with the neuropathological findings of neuromyelitis optica spinal lesions. Moreover, loss of AQP4 was observed in the gray matter. The presence of anti-AQP4 antibodies, and the pathology, led to the diagnosis of anti-AQP4 antibodies-related encephalopathy.

Original languageEnglish
Pages (from-to)683-687
Number of pages5
JournalMultiple Sclerosis Journal
Volume18
Issue number5
DOIs
Publication statusPublished - 2012 May

Keywords

  • Anti-aquaporin4 (AQP4) antibodies
  • encephalopathy
  • pathology
  • pregnancy

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Fingerprint

Dive into the research topics of 'Pathological study of subacute autoimmune encephalopathy with anti-AQP4 antibodies in a pregnant woman'. Together they form a unique fingerprint.

Cite this