Pathological effects on mice by gambierol, possibly one of the ciguatera toxins

Emiko Ito, Fumie Suzuki-Toyota, Kiyotaka Toshimori, Haruhiko Fuwa, Kazuo Tachibana, Masayuki Satake, Makoto Sasaki

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Gambierol was isolated from Gambierdiscus toxicus, which causes ciguatera fish poisoning. The acute toxicological effects induced in mice by synthesized gambierol were studied. The lethal doses were about 80 μg/kg by i.p. and i.v., and 150 μg/kg by p.o. The main injury by this toxin was observed in the lung, and secondary in the heart, resulting in systemic congestion. Another toxic effect was seen in the stomach, inducing hypersecretion and ulceration. With survival from the severe stage during the initial 3 h, recovery was favorable, especially after 4 days. Additional effects were not evident during 1-week post-administration observation.

Original languageEnglish
Pages (from-to)733-740
Number of pages8
JournalToxicon
Volume42
Issue number7
DOIs
Publication statusPublished - 2003 Dec

Keywords

  • Alveolar macrophage
  • Gambierol
  • Mouse
  • Pathological effect

ASJC Scopus subject areas

  • Toxicology

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    Ito, E., Suzuki-Toyota, F., Toshimori, K., Fuwa, H., Tachibana, K., Satake, M., & Sasaki, M. (2003). Pathological effects on mice by gambierol, possibly one of the ciguatera toxins. Toxicon, 42(7), 733-740. https://doi.org/10.1016/j.toxicon.2003.09.011