Paternal dual barrier by Ifg2-H19 and Dlk1-Gtl2 to parthenogenesis in mice.

T. Kono, M. Kawahara, Q. Wu, H. Hiura, Y. Obata

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

The functional difference between the maternal and paternal genome, which is characterized by epigenetic modifications during gametogenesis, that is genomic imprinting, prevents mammalian embryos from parthenogenesis. Genomic imprinting leads to nonequivalent expression of imprinted genes from the maternal and paternal alleles. However, our research showed that alteration of maternal imprinting by oocyte reconstruction using nongrowing oocytes together with deletion of the H19 gene, provides appropriate expression of maternally imprinted genes. Here we discuss that further alteration of paternally imprinted gene expressions at chromosomes 7 and 12 allows the ng/fg parthenogenetic embryos to develop to term, suggesting that the paternal contribution is obligatory for the descendant.

Original languageEnglish
Pages (from-to)23-33
Number of pages11
JournalErnst Schering Research Foundation workshop
Issue number60
DOIs
Publication statusPublished - 2006

ASJC Scopus subject areas

  • Medicine(all)

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