Passive smoking at home and cancer risk: A population-based prospective study in Japanese nonsmoking women

Yoshikazu Nishino, Yoshitaka Tsubono, Ichiro Tsuji, Shoko Komatsu, Seiki Kanemura, Haruo Nakatsuka, Akira Fukao, Hiroshi Satoh, Shigeru Hisamichi

Research output: Contribution to journalArticlepeer-review

63 Citations (Scopus)


Objectives: To investigate the relationship between passive smoking at home and the incidence of various cancers in a population-based prospective study. Methods: The subjects were 9675 Japanese lifelong nonsmoking women aged over 40 years who lived in three municipalities of Miyagi Prefecture, and completed a self-administration questionnaire in 1984. During 9 years of follow-up, 426 cancers were identified by record linkage to the population-based cancer registry. The data were analyzed using the Cox proportional hazards model. Results: The age-adjusted relative risks (RR) and 95% confidence intervals (CI) of smoking-related cancers and lung cancer for women who had smoking husbands, compared with women whose husbands did not smoke, were 1.7 (0.94-2.9, p = 0.079) and 1.9 (0.81-4.4, p = 0.14), respectively. In contrast, a significant inverse association was observed for breast cancer; the RR (95% CI) was 0.58 (0.34-0.99, p = 0.047). After multivariate adjustment for confounding factors, the risks of smoking-related cancers and breast cancer were materially unchanged. Conclusions: These results show that passive smoking may affect the risk of cancers other than lung cancer.

Original languageEnglish
Pages (from-to)797-802
Number of pages6
JournalCancer Causes and Control
Issue number9
Publication statusPublished - 2001
Externally publishedYes


  • Breast neoplasms
  • Environmental tobacco smoke
  • Involuntary tobacco smoke
  • Japan
  • Lung neoplasms
  • Passive smoking
  • Prospective study
  • Tobacco smoke pollution

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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