We measured lateral pressure in airways 3 mm in internal diameter in three normal subjects using an anterograde catheter with a tip micromanometer. The pressure was used to partition total pulmonary resistance into a large airway resistance component between the mouth and the pressure sensor and a small airway resistance component between the pressure sensor and alveoli. Large airway resistance and small airway resistance during inspiration were 2.3±0.4 and 0.9±0.2 cmH20/liter/sec (mean±s.E.), respectively, and small airway resistance was 29% of the total pulmonary resistance. We suggest that the present technique may be useful for determining the localization of airway resistance in human subjects.
- bronchial pressure
- catheter tip micromanometer
- pulmonary resistance
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)