Particular human leukocyte antigen alleles are associated with biochemical traits in the Japanese population

Shigeki Mitsunaga, Yasuhiko Homma, Akira Narita, Koichi Kashiwase, Yuko Okudaira, Yutaka Shiina, Ituro Inoue, Hidetoshi Inoko

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

We analyzed genetic associations among 7 biochemical traits (fasting plasma glucose, HbA1c, total cholesterol, low-density lipoprotein [LDL] cholesterol, high-density lipoprotein cholesterol, triglyceride, and uric acid) and 6 HLA loci using 1,616 individuals who visited the Health Evaluation and Promotion Center at Tokai University Hospital. Significant differences between the individuals carrying particular HLA alleles and those not carrying the alleles in certain biochemical traits were observed by Mann-Whitney U test. In female subjects, DPB1*03:01 was significantly associated with HbA1c (p = 0.0000665), and DRB1*14:03 was associated with total cholesterol concentration (p = 0.0015). In male subjects, C*14:02 demonstrated significant associations with fasting plasma glucose with p values of 0.0041. By contrast, Fisher's exact test indicated that female DRB1*14:03 was associated with a high concentration of total cholesterol (p = 000323, odds ratio [OR] = 4.32, 95% confidence interval [95% CI] = 1.83-10.36), whereas female DPB1*02:01 had a protective effect against a high concentration of LDL cholesterol (p =0.0043, OR = 0.41, 95% CI = 0.19-0.79). These associations have a statistical power of more than 0.8 and still retain significance after Bonferroni correction.

Original languageEnglish
Pages (from-to)566-570
Number of pages5
JournalHuman Immunology
Volume72
Issue number7
DOIs
Publication statusPublished - 2011 Jul

Keywords

  • Association
  • Biochemical trait
  • HLA

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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