Particle method simulation of red blood cells infected by malaria

Takami Yamaguchi, Young Ho Kang, Hitoshi Kondo, Yohsuke Imai, Takuji Ishikawa

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

When a malaria parasite invades and matures inside a red blood cell (RBC), the infected RBC (IRBC) becomes stiffer and cytoadherent and these two outcomes can lead to microvascular blockage. We propose a numerical model of the three-dimensional hemodynamics in malaria infection. Our model is based on a Lagrangian and free mesh method (particle method). We employ spring network of membrane particles for representing deformation of RBC membrane. Adhesive property of IRBCs to surrounding cells is also expressed by using a spring model. Our method would be helpful for further understandings of pathology of malaria-infection.

Original languageEnglish
Title of host publicationWorld Congress on Medical Physics and Biomedical Engineering
Subtitle of host publicationImage Processing, Biosignal Processing, Modelling and Simulation, Biomechanics
PublisherSpringer Verlag
Pages393-394
Number of pages2
Edition4
ISBN (Print)9783642038815
DOIs
Publication statusPublished - 2009
EventWorld Congress on Medical Physics and Biomedical Engineering: Image Processing, Biosignal Processing, Modelling and Simulation, Biomechanics - Munich, Germany
Duration: 2009 Sep 72009 Sep 12

Publication series

NameIFMBE Proceedings
Number4
Volume25
ISSN (Print)1680-0737

Other

OtherWorld Congress on Medical Physics and Biomedical Engineering: Image Processing, Biosignal Processing, Modelling and Simulation, Biomechanics
CountryGermany
CityMunich
Period09/9/709/9/12

Keywords

  • Computational fluid dynamics
  • Hemodynamics
  • Malaria
  • Micro circulation
  • Particle method
  • Red blood cell

ASJC Scopus subject areas

  • Bioengineering
  • Biomedical Engineering

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