TY - JOUR
T1 - Participation of macrophages in segmental endocapillary proliferation preceding focal glomerular sclerosis
AU - Saito, Takao
AU - Ootaka, Tetsuya
AU - Sato, Hiroshi
AU - Furuta, Takashi
AU - Sato, Toshinobu
AU - Soma, Jun
AU - Abe, Keishi
AU - Yoshinaga, Kaoru
N1 - Copyright:
Copyright 2016 Elsevier B.V., All rights reserved.
PY - 1993/6
Y1 - 1993/6
N2 - We studied infiltrating cells in the glomeruli of eight cases with focal segmental endocapillary proliferation (FSEP) using monoclonal antibodies to leukocyte common antigen, T cells, B cells, and monocytes/macrophages (Mo/Mφ). It was demonstrated by sequential biopsies performed in five cases that FSEP preceded focal glomerular sclerosis (FGS). Cell types in FSEP were compared with those in FGS from 17 patients with persistent nephrotic syndrome, ten non‐nephrotic patients, and eight patients with nephrotic syndrome which was initially responsive to steroid therapy but relapsed, as well as minimal change specimens from nine nephrotic patients. In the glomeruli, the mean total leukocyte counts increased significantly in the FSEP group (P < 0.01). The serial sections in FSEP revealed that Mo/Mφ were the predominant cells and were localized in areas of endocapillary proliferation. T‐cell or B‐cell infiltration was less marked. The extensive intracapillary distribution of p150,95 antigen belonging to the integrin family and acting as a C3bi receptor suggested that FSEP may be mediated by adhesion molecules expressed on Mo/Mφ. These findings indicate that Mo/Mφ may play a key role in FGS which shows endocapillary proliferation in the initial stage.
AB - We studied infiltrating cells in the glomeruli of eight cases with focal segmental endocapillary proliferation (FSEP) using monoclonal antibodies to leukocyte common antigen, T cells, B cells, and monocytes/macrophages (Mo/Mφ). It was demonstrated by sequential biopsies performed in five cases that FSEP preceded focal glomerular sclerosis (FGS). Cell types in FSEP were compared with those in FGS from 17 patients with persistent nephrotic syndrome, ten non‐nephrotic patients, and eight patients with nephrotic syndrome which was initially responsive to steroid therapy but relapsed, as well as minimal change specimens from nine nephrotic patients. In the glomeruli, the mean total leukocyte counts increased significantly in the FSEP group (P < 0.01). The serial sections in FSEP revealed that Mo/Mφ were the predominant cells and were localized in areas of endocapillary proliferation. T‐cell or B‐cell infiltration was less marked. The extensive intracapillary distribution of p150,95 antigen belonging to the integrin family and acting as a C3bi receptor suggested that FSEP may be mediated by adhesion molecules expressed on Mo/Mφ. These findings indicate that Mo/Mφ may play a key role in FGS which shows endocapillary proliferation in the initial stage.
KW - Endocapillary proliferation
KW - adhesion molecule
KW - focal glomerular sclerosis
KW - macrophage
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U2 - 10.1002/path.1711700214
DO - 10.1002/path.1711700214
M3 - Article
C2 - 8345408
AN - SCOPUS:0027160367
VL - 170
SP - 179
EP - 185
JO - Investigative and Cell Pathology
JF - Investigative and Cell Pathology
SN - 0022-3417
IS - 2
ER -