Participation of angiotensin II in pressor response and norepinephrine release to spinal nerve stimulation in pithed rats

Y. Mizunuma, M. Suzuki-Kusaba, H. Hisa, M. Yoshida, S. Satoh

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

Experiments were carried out to examine whether endogenous angiotensin II (A-II) is involved in the regulation of release of norepinephrine (NE) elicited by the stimulation of spinal sympathetic nerves in pithed rats. It was assessed in terms of the alterations in concentrations of arterial blood plasma A-II and NE elicited by nerve stimulation (5 Hz, 50 V, 1 msec for 45 s) in pithed rats under vehicle or captopril (3 mg/kg, i.v.) treatment. Comparative study with pentobarbital anesthetized rats showed that pithing rats have the characteristics of lower basal blood pressure and lower NE level, whereas they have higher basal A-II level. In pithed rats treated with vehicle, pressor response to nerve stimulation was accompanied by increases in both A-II and NE level. In rats treated with captopril, the nerve stimulation caused about 40% lower increases in pressor response and NE level than those observed in rats treated with vehicle. These results suggest that the sympathetic nerve-induced NE release is facilitated by endogenous A-II in pithed rats, and that captopril exerts its inhibitory effect on the pressor response to nerve stimulation through the suppression of this interaction.

Original languageEnglish
Pages (from-to)1455-1457
Number of pages3
JournalBiological and Pharmaceutical Bulletin
Volume23
Issue number12
DOIs
Publication statusPublished - 2000

Keywords

  • Angiotensin II
  • Captopril
  • Norepinephrine release
  • Sympathetic nerve

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science

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