Partial structures and binding studies of maitotoxin, the most potent marine toxin.

M. Murata, M. Sasaki, A. Yokoyama, T. Iwashita, F. Gusovsky, J. W. Daly, T. Yasumoto

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

Partial structures of maitotoxin (MTX) were deduced by extensive two-dimensional NMR measurements, showing that the toxin had carbon-carbon double bonds in both termini of the molecule, and a primary alcohol group at the end. These functionalities were used for preparation of a radioligand of MTX; [3H]H-MTX and [3H]benzoyl-MTX. Both radioligands had high levels of non-specific binding to tissues. The binding of [3H]MTX to rat glioma C6 cells was inhibited by a didesulfo-MTX, suggesting the presence of the specific site for MTX-binding on the external surface of the cell membrane.

Original languageEnglish
Pages (from-to)470-473
Number of pages4
JournalBulletin de la Société de pathologie exotique (1990)
Volume85
Issue number5 Pt 2
Publication statusPublished - 1992

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Fingerprint Dive into the research topics of 'Partial structures and binding studies of maitotoxin, the most potent marine toxin.'. Together they form a unique fingerprint.

Cite this