TY - JOUR
T1 - Partial exposure of frog heart to high-potassium solution
T2 - An easily reproducible model mimicking ST segment changes
AU - Kon, Nobuaki
AU - Abe, Nozomu
AU - Miyazaki, Masahiro
AU - Mushiake, Hajime
AU - Kazama, Itsuro
N1 - Funding Information:
ACKNOWLEDGMENTS. This work was supported by MEXT KAKENHI Grant, No. 16K08484, the Salt Science Research Foundation, No.1725 and the Intelligent Cosmos Scientific Foundation Grant to IK.
Publisher Copyright:
© 2018 The Japanese Society of Veterinary Science.
PY - 2018/4
Y1 - 2018/4
N2 - By simply inducing burn injuries on the bullfrog heart, we previously reported a simple model of abnormal ST segment changes observed in human ischemic heart disease. In the present study, instead of inducing burn injuries, we partially exposed the surface of the frog heart to high-potassium (K+) solution to create a concentration gradient of the extracellular K+ within the myocardium. Dual recordings of ECG and the cardiac action potential demonstrated significant elevation of the ST segment and the resting membrane potential, indicating its usefulness as a simple model of heart injury. Additionally, from our results, Na+/K+ -ATPase activity was thought to be primarily responsible for generating the K+ concentration gradient and inducing the ST segment changes in ECG.
AB - By simply inducing burn injuries on the bullfrog heart, we previously reported a simple model of abnormal ST segment changes observed in human ischemic heart disease. In the present study, instead of inducing burn injuries, we partially exposed the surface of the frog heart to high-potassium (K+) solution to create a concentration gradient of the extracellular K+ within the myocardium. Dual recordings of ECG and the cardiac action potential demonstrated significant elevation of the ST segment and the resting membrane potential, indicating its usefulness as a simple model of heart injury. Additionally, from our results, Na+/K+ -ATPase activity was thought to be primarily responsible for generating the K+ concentration gradient and inducing the ST segment changes in ECG.
KW - Bullfrog heart
KW - Ischemic heart disease
KW - Na/K -ATPase activity
KW - Partial exposure to high-potassium solution
KW - ST segment change
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U2 - 10.1292/jvms.18-0010
DO - 10.1292/jvms.18-0010
M3 - Comment/debate
C2 - 29503350
AN - SCOPUS:85045643829
VL - 80
SP - 578
EP - 582
JO - Journal of Veterinary Medical Science
JF - Journal of Veterinary Medical Science
SN - 0916-7250
IS - 4
ER -
