PARP-1 controls immunosuppressive function of regulatory T cells by destabilizing Foxp3.

Agriculture & Biology

• NAD ADP-ribosyltransferase 100%
• immunosuppressive agents 79%
• T-lymphocytes 61%
• loss-of-function mutation 12%
• intergenic DNA 9%
• inflammation 8%
• transcription factors 7%
• genes 6%
• nucleotide sequences 6%
• gene expression 5%
• mice 5%

Medicine & Life Sciences

• Poly (ADP-Ribose) Polymerase-1 93%
• Regulatory T-Lymphocytes 67%
• Immunosuppressive Agents 56%
• Loss of Function Mutation 10%
• Genes 7%
• Transcription Factors 7%
• T-Lymphocytes 5%
• Gene Expression 5%
• Enzymes 5%

Chemical Compounds

• Poly(ADPribose) 92%
• DNA Sequence 10%
• Mutation 8%