TY - JOUR
T1 - Parkinsonism During Cyclosporine Treatment in Liver Transplantation
T2 - An Unusual Case Report
AU - Miyagi, S.
AU - Sekiguchi, S.
AU - Kawagishi, N.
AU - Akamatsu, Y.
AU - Sato, A.
AU - Fujimori, K.
AU - Satomi, S.
N1 - Funding Information:
Supported by Grants-in–Aid for Scientific Research from the Ministry of Education, Science, and Culture of Japan, and from the Ministry of Welfare of Japan, and by a grant from Tohoku University Graduate School of Medicine.
PY - 2008/10
Y1 - 2008/10
N2 - Objectives: Cyclosporine (CyA) has been associated with various neurological reactions but parkinsonism is not generally recognized as a nervous system side effect. We describe herein a rare case, in that the patient developed parkinsonism with rest tremor after receiving CyA following orthotopic liver transplantation (OLT). Methods: The patient was a 42-year-old man who had liver cirrhosis with hepatitis C. We performed OLT because of liver failure and started immunosuppressive therapy with CyA + methylprednisolone + CD25 antibody. Ten days after OLT, he developed parkinsonism with a rest tremor. The patient did not have a pre-existent neurological disorder, and had not received significant amounts of dopamine-blocking drugs. Results: We administered levodopa with marked improvement. Three days after that event, the neurologist suggested the possibility of drug-induced parkinsonism. We converted the immunosuppressive drug from CyA to tacrolimus. After that, the symptom disappeared. At 75 days after OLT, he was discharged with no neurological medication and now he is completely recovered. Conclusion: We think that parkinsonism may be an occasional consequence of CyA because of its relation to withdrawal of the drug and the lack of another evident cause.
AB - Objectives: Cyclosporine (CyA) has been associated with various neurological reactions but parkinsonism is not generally recognized as a nervous system side effect. We describe herein a rare case, in that the patient developed parkinsonism with rest tremor after receiving CyA following orthotopic liver transplantation (OLT). Methods: The patient was a 42-year-old man who had liver cirrhosis with hepatitis C. We performed OLT because of liver failure and started immunosuppressive therapy with CyA + methylprednisolone + CD25 antibody. Ten days after OLT, he developed parkinsonism with a rest tremor. The patient did not have a pre-existent neurological disorder, and had not received significant amounts of dopamine-blocking drugs. Results: We administered levodopa with marked improvement. Three days after that event, the neurologist suggested the possibility of drug-induced parkinsonism. We converted the immunosuppressive drug from CyA to tacrolimus. After that, the symptom disappeared. At 75 days after OLT, he was discharged with no neurological medication and now he is completely recovered. Conclusion: We think that parkinsonism may be an occasional consequence of CyA because of its relation to withdrawal of the drug and the lack of another evident cause.
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U2 - 10.1016/j.transproceed.2008.07.053
DO - 10.1016/j.transproceed.2008.07.053
M3 - Article
C2 - 18929871
AN - SCOPUS:53349151833
VL - 40
SP - 2823
EP - 2824
JO - Transplantation Proceedings
JF - Transplantation Proceedings
SN - 0041-1345
IS - 8
ER -