Parasympathetic reflex vasodilatation in rat submandibular gland

Kentaro Mizuta, Keishiro Karita, Hiroshi Izumi

Research output: Contribution to journalArticlepeer-review

33 Citations (Scopus)

Abstract

The present study was designed to investigate 1) whether parasympathetic reflex vasodilatation occurs in the submandibular gland (SMG) in deeply urethan-anesthetized, cervically vagotomized, and sympathectomized rats when the central cut end of the lingual nerve (LN) is electrically stimulated and 2) to what extent the neural mechanisms underlying such responses are the same as those involved in the response to direct stimulation of the chorda-LN (CLN). Stimulation of each nerve separately elicited a marked blood flow increase in SMG. Section of the chorda tympani abolished the SMG blood flow response but had no effect on the lip blood flow increase evoked by LN stimulation. Section of the CLN abolished the SMG blood flow increases evoked by stimulation of either nerve. The SMG blood flow increases (regardless of whether they were evoked by LN or CLN stimulation) were markedly reduced by the autonomic cholinergic ganglion blocker hexamethonium. The present study demonstrates that a parasympathetic reflex vasodilator mechanism is present in the rat SMG and that it can express its effects under deep general anesthesia.

Original languageEnglish
Pages (from-to)R677-R683
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Volume279
Issue number2 48-2
DOIs
Publication statusPublished - 2000

Keywords

  • Atropine
  • Autonomic ganglionic blocker
  • Autonomic reflex
  • Orofacial area
  • Vasoresponse

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

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