Paraoxonase 1 gene polymorphisms influence clinical features of open-angle glaucoma

Yoko Inagaki, Yukihiko Mashima, Tomoyo Funayama, Yuichiro Ohtake, Nobuo Fuse, Noriko Yasuda, Takeo Fukuchi, Akira Murakami, Yoshihiro Hotta

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)

Abstract

Background: The purpose of this study was to determine whether genetic polymorphisms affecting high-density lipoprotein (HDL)-associated antioxidant enzymes were associated with open-angle glaucoma (OAG). The rationale for this study was that the modification of low-density lipoprotein (LDL) by HDL prevents oxidative modification which can then cause dysfunction of endothelial cells. Methods: We studied 284 normal Japanese controls and 555 Japanese patients with OAG, including primary open-angle glaucoma (POAG) and normal-tension glaucoma (NTG). The possible associations of polymorphisms of PON1/L55M, PON1/Q192R, PON2/S311C, and PAF-AH/V279F with OAG were investigated. We compared the genotype distributions and allele frequency in controls and patient groups. The age at diagnosis, intraocular pressure (IOP) at diagnosis, and visual field score at diagnosis were examined for association with polymorphisms. Results: The distributions of genotypes and allele frequency for the four polymorphisms were not significantly different between any patient group and controls. In NTG patients, 55M carriers of the PON1 gene were significantly older at diagnosis than 55M non-carriers (P=0.001). The IOP at diagnosis was significantly higher in glaucoma patients carrying 192R in the PON1 gene than in patients not carrying 192R (P=0.006). No significant differences were seen in clinical characteristics of OAG patients in relation to other polymorphisms. Conclusion: PON1 gene polymorphisms may influence the features of Japanese patients with OAG.

Original languageEnglish
Pages (from-to)984-990
Number of pages7
JournalGraefe's Archive for Clinical and Experimental Ophthalmology
Volume244
Issue number8
DOIs
Publication statusPublished - 2006 Aug

Keywords

  • Genetic polymorphisms
  • Intraocular pressure
  • Normal-tension glaucoma
  • Open-angle glaucoma
  • Paraoxonase 1

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

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