Parallel synthesis of oligosaccharide conjugated enediynes onto silyl-linked solid-support

A. Matsuda, T. Doi, H. Tanaka, T. Takahashi

Research output: Contribution to journalArticlepeer-review

25 Citations (Scopus)

Abstract

A solid-phase synthesis of enediyne molecules containing a sugar moiety is reported. Polymer-supported (2-mercaptoethyl)glycosides linked through a trialkylsilane linker were coupled to a bromoacetate on an enediyne by S-alkylation. After simple washing of the polymer, mild acid treatment, and evaporation, the desired oligosaccharide conjugated enediynes were isolated in pure form in parallel fashion.

Original languageEnglish
Pages (from-to)1101-1104
Number of pages4
JournalSynlett
Issue number7
Publication statusPublished - 2001 Jan 1
Externally publishedYes

Keywords

  • Coupling
  • Oligosaccharides
  • Solid-phase synthesis
  • Thiols

ASJC Scopus subject areas

  • Organic Chemistry

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