A solid-phase synthesis of enediyne molecules containing a sugar moiety is reported. Polymer-supported (2-mercaptoethyl)glycosides linked through a trialkylsilane linker were coupled to a bromoacetate on an enediyne by S-alkylation. After simple washing of the polymer, mild acid treatment, and evaporation, the desired oligosaccharide conjugated enediynes were isolated in pure form in parallel fashion.
|Number of pages||4|
|Publication status||Published - 2001 Jan 1|
- Solid-phase synthesis
ASJC Scopus subject areas
- Organic Chemistry