Parallel simulation of cellular flow in microvessels using a particle method

Davod Alizadehrad, Yohsuke Imai, Keita Nakaaki, Takuji Ishikawa, Takami Yamaguchi

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

We developed a numerical method for large-scale simulations of cellular flow in microvessels. We employed a particle method, where all blood components were modeled using a finite number of particles. Red blood cell deformation was modeled by a spring network of membrane particles. A domain decomposition method was used for parallel implementation on distributed memory systems. In a strong scaling test up to 64 CPU cores, we obtained a linear speedup with the number of CPU cores, and demonstrated that our model can simulate O(10 3) red blood cells in vessels a few tens of micrometers in diameter. For quantitative validation, we analyzed the Fåhræus effect and the formation of a cell-depleted peripheral layer. Simulations were performed for tube hematocrit ranging from 20 to 45%, and microvessel diameters from 9 to 50 μm. Our numerical results were in good agreement with previous experimental results both for the discharge hematocrit and cell-depleted peripheral layer thickness.

Original languageEnglish
Pages (from-to)57-71
Number of pages15
JournalJournal of Biomechanical Science and Engineering
Volume7
Issue number1
DOIs
Publication statusPublished - 2012 Feb 29

Keywords

  • Cell-depleted peripheral layer
  • Fåhræus effect
  • Large-scale simulation
  • Microcirculation
  • Red blood cell

ASJC Scopus subject areas

  • Biomedical Engineering

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