Paradoxical progression of biliary strictures against recovery of biochemical parameters under ursodeoxycholic acid treatment in a case of primary sclerosing cholangitis with ulcerative colitis

Koga Komatsu, Tooru Shimosegawa, Satoru Kikuchi, Midori Uchi, Yoshisuke Maruhama, Norihiro Kisara, Yoshiyuki Ueno, Takayoshi Toyota

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1 Citation (Scopus)

Abstract

Ursodeoxycholic acid (UDCA) treatment for primary sclerosing cholangitis (PSC) has been considered a rational therapy, though its effectiveness in the clinical course is still open to discussion. In this report, we describe a 22-year-old man with PSC at an early stage, which was associated with ulcerative colitis (UC). He showed progressive strictures of bile ducts over a 1.5-year period in spite of an improvement in the biochemical parameters by UDCA treatment. Therefore, care should be taken in interpreting the effectiveness of UDCA, because the biochemical parameters may not change in parallel with the clinical course of PSC.

Original languageEnglish
Pages (from-to)1049-1053
Number of pages5
JournalInternal Medicine
Volume39
Issue number12
DOIs
Publication statusPublished - 2000 Dec

Keywords

  • Endoscopic retrograde cholangiopancreatography
  • Mesalazine
  • Progressive biliary strictures

ASJC Scopus subject areas

  • Internal Medicine

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