Paradoxical progression of biliary strictures against recovery of biochemical parameters under ursodeoxycholic acid treatment in a case of primary sclerosing cholangitis with ulcerative colitis

Koga Komatsu; Tooru Shimosegawa; Satoru Kikuchi; Midori Uchi; Yoshisuke Maruhama; Norihiro Kisara; Yoshiyuki Ueno; Takayoshi Toyota

doi:10.2169/internalmedicine.39.1049

Paradoxical progression of biliary strictures against recovery of biochemical parameters under ursodeoxycholic acid treatment in a case of primary sclerosing cholangitis with ulcerative colitis

Koga Komatsu, Tooru Shimosegawa, Satoru Kikuchi, Midori Uchi, Yoshisuke Maruhama, Norihiro Kisara, Yoshiyuki Ueno, Takayoshi Toyota

MED - Medical Sciences

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

Ursodeoxycholic acid (UDCA) treatment for primary sclerosing cholangitis (PSC) has been considered a rational therapy, though its effectiveness in the clinical course is still open to discussion. In this report, we describe a 22-year-old man with PSC at an early stage, which was associated with ulcerative colitis (UC). He showed progressive strictures of bile ducts over a 1.5-year period in spite of an improvement in the biochemical parameters by UDCA treatment. Therefore, care should be taken in interpreting the effectiveness of UDCA, because the biochemical parameters may not change in parallel with the clinical course of PSC.

Original language	English
Pages (from-to)	1049-1053
Number of pages	5
Journal	Internal Medicine
Volume	39
Issue number	12
DOIs	https://doi.org/10.2169/internalmedicine.39.1049
Publication status	Published - 2000 Dec

Keywords

Endoscopic retrograde cholangiopancreatography
Mesalazine
Progressive biliary strictures

ASJC Scopus subject areas

Internal Medicine

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10.2169/internalmedicine.39.1049

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Komatsu, K., Shimosegawa, T., Kikuchi, S., Uchi, M., Maruhama, Y., Kisara, N., Ueno, Y., & Toyota, T. (2000). Paradoxical progression of biliary strictures against recovery of biochemical parameters under ursodeoxycholic acid treatment in a case of primary sclerosing cholangitis with ulcerative colitis. Internal Medicine, 39(12), 1049-1053. https://doi.org/10.2169/internalmedicine.39.1049

Paradoxical progression of biliary strictures against recovery of biochemical parameters under ursodeoxycholic acid treatment in a case of primary sclerosing cholangitis with ulcerative colitis. / Komatsu, Koga; Shimosegawa, Tooru; Kikuchi, Satoru; Uchi, Midori; Maruhama, Yoshisuke; Kisara, Norihiro; Ueno, Yoshiyuki; Toyota, Takayoshi.

In: Internal Medicine, Vol. 39, No. 12, 12.2000, p. 1049-1053.

Research output: Contribution to journal › Article › peer-review

Komatsu, K, Shimosegawa, T, Kikuchi, S, Uchi, M, Maruhama, Y, Kisara, N, Ueno, Y & Toyota, T 2000, 'Paradoxical progression of biliary strictures against recovery of biochemical parameters under ursodeoxycholic acid treatment in a case of primary sclerosing cholangitis with ulcerative colitis', Internal Medicine, vol. 39, no. 12, pp. 1049-1053. https://doi.org/10.2169/internalmedicine.39.1049

Komatsu, Koga ; Shimosegawa, Tooru ; Kikuchi, Satoru ; Uchi, Midori ; Maruhama, Yoshisuke ; Kisara, Norihiro ; Ueno, Yoshiyuki ; Toyota, Takayoshi. / Paradoxical progression of biliary strictures against recovery of biochemical parameters under ursodeoxycholic acid treatment in a case of primary sclerosing cholangitis with ulcerative colitis. In: Internal Medicine. 2000 ; Vol. 39, No. 12. pp. 1049-1053.

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abstract = "Ursodeoxycholic acid (UDCA) treatment for primary sclerosing cholangitis (PSC) has been considered a rational therapy, though its effectiveness in the clinical course is still open to discussion. In this report, we describe a 22-year-old man with PSC at an early stage, which was associated with ulcerative colitis (UC). He showed progressive strictures of bile ducts over a 1.5-year period in spite of an improvement in the biochemical parameters by UDCA treatment. Therefore, care should be taken in interpreting the effectiveness of UDCA, because the biochemical parameters may not change in parallel with the clinical course of PSC.",

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AB - Ursodeoxycholic acid (UDCA) treatment for primary sclerosing cholangitis (PSC) has been considered a rational therapy, though its effectiveness in the clinical course is still open to discussion. In this report, we describe a 22-year-old man with PSC at an early stage, which was associated with ulcerative colitis (UC). He showed progressive strictures of bile ducts over a 1.5-year period in spite of an improvement in the biochemical parameters by UDCA treatment. Therefore, care should be taken in interpreting the effectiveness of UDCA, because the biochemical parameters may not change in parallel with the clinical course of PSC.

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Paradoxical progression of biliary strictures against recovery of biochemical parameters under ursodeoxycholic acid treatment in a case of primary sclerosing cholangitis with ulcerative colitis

Abstract

Keywords

ASJC Scopus subject areas

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