Papillary collecting tubule responsiveness to vasoactive hormones in spontaneously hypertensive rats

Makito Sato, Keishi Abe, Kazuhisa Takeuchi, Minoru Yasujima, Shounan Fang, Masayuki Kanazawa, Kazunori Yoshida, Kaoru Yoshinaga

Research output: Contribution to journalArticlepeer-review

Abstract

Renal papillary collecting tubule (RPCT) hormone responsiveness was compared between cultured RPCT cells from spontaneously hypertensive rats (SHR) and Wistar-Kyoto rats (WKY). Unstimulated cells from 4-week-old SHR produced less prostaglandin E2(PGE2) and cyclic (c)AMP than comparable cells from WKY, while cells from both strains synthesized similar amounts of PGE2after stimulation with arachidonate, A23187 or bradykinin and similar amounts of cAMP after stimulation with vasopressin or PGE2. There was no difference in basai or stimulated levels of cyclic (c)GMP between the strains. In RPCT cells from 16-week-old rats, basal levels of cAMP, cGMP and PGE2were significantly lower than those from 4-week-old rats, but they did not differ between the strains. These results suggest that RPCT cells of SHR and WKY at the post-weaning period may differ in the metabolism of PGE2and cAMP. This difference may be attributed to the possible defect in arachidonate availability in SHR.

Original languageEnglish
Pages (from-to)S476-S478
JournalJournal of Hypertension, Supplement
Volume6
Issue number4
DOIs
Publication statusPublished - 1988 Dec

Keywords

  • Arachidonic acid
  • Cyclic adenosine monophosphate
  • Cyclic guanosine monophosphate
  • Papillary collecting tubule
  • Prostaglandin E
  • Spontaneously hypertensive rat
  • Vasopressin
  • Wistar-Kyoto rat

ASJC Scopus subject areas

  • Internal Medicine
  • Physiology
  • Cardiology and Cardiovascular Medicine

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