Panton–valentíne leukocidin genes in a phage-like particle isolated from mitomycin C-Treated staphylococcus aureus V8 (ATCC 49775)

Jun Kaneko, Takahiro Kimura, Yoshiyuki Kawakami, Toshio Tomita, Yoshiyuki Kamio

    Research output: Contribution to journalArticlepeer-review

    70 Citations (Scopus)

    Abstract

    The staphylococcal Panton–Valentine leukocidin (PVL) genes [lukS-PV-lukF-PV] existed in a hexagonal phage-like particle (ϕPVL) isolated from mitomycin C-induced Staphylococcus aureus V8 (ATCC 49775). The genome packed in ϕPVL was a linear double-stranded 40-kb DNA with single-stranded cohesive ends (cos). The [lukS-PV-lukS-PV], attP, and int (integrase géne) of ϕPVL were all located very close to one another within a 4.0 kb-segment on the genome in the order given, and the segment is located at the center from the left and the right cos sites. In addition, the [lukS-PV-lukF-PV]-attP-int region contains 5 direct repeat sequences that show high similarity with the recombinase-binding sites of bacteriophages of S. aureus.

    Original languageEnglish
    Pages (from-to)1960-1962
    Number of pages3
    JournalBioscience, Biotechnology and Biochemistry
    Volume61
    Issue number11
    DOIs
    Publication statusPublished - 1997 Jan

    Keywords

    • Carrying Panton-Valentine leukocidin genes
    • Integrase
    • LukF-PV
    • Luks-PV
    • Staphylococcus aureus V8 (ATCC 49775)
    • Temperate phage (πPVL)

    ASJC Scopus subject areas

    • Biotechnology
    • Analytical Chemistry
    • Biochemistry
    • Applied Microbiology and Biotechnology
    • Molecular Biology
    • Organic Chemistry

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