Panton–valentíne leukocidin genes in a phage-like particle isolated from mitomycin C-Treated staphylococcus aureus V8 (ATCC 49775)

Jun Kaneko, Takahiro Kimura, Yoshiyuki Kawakami, Toshio Tomita, Yoshiyuki Kamio

Research output: Contribution to journalArticle

67 Citations (Scopus)

Abstract

The staphylococcal Panton–Valentine leukocidin (PVL) genes [lukS-PV-lukF-PV] existed in a hexagonal phage-like particle (ϕPVL) isolated from mitomycin C-induced Staphylococcus aureus V8 (ATCC 49775). The genome packed in ϕPVL was a linear double-stranded 40-kb DNA with single-stranded cohesive ends (cos). The [lukS-PV-lukS-PV], attP, and int (integrase géne) of ϕPVL were all located very close to one another within a 4.0 kb-segment on the genome in the order given, and the segment is located at the center from the left and the right cos sites. In addition, the [lukS-PV-lukF-PV]-attP-int region contains 5 direct repeat sequences that show high similarity with the recombinase-binding sites of bacteriophages of S. aureus.

Original languageEnglish
Pages (from-to)1960-1962
Number of pages3
JournalBioscience, Biotechnology and Biochemistry
Volume61
Issue number11
DOIs
Publication statusPublished - 1997 Jan

Keywords

  • Carrying Panton-Valentine leukocidin genes
  • Integrase
  • LukF-PV
  • Luks-PV
  • Staphylococcus aureus V8 (ATCC 49775)
  • Temperate phage (πPVL)

ASJC Scopus subject areas

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry

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