Panretinal photocoagulation induces pro-inflammatory cytokines and macular thickening in high-risk proliferative diabetic retinopathy

Masahiko Shimura, Kanako Yasuda, Toru Nakazawa, Toshiaki Abe, Takashi Shiono, Tomohiro Iida, Taiji Sakamoto, Kohji Nishida

Research output: Contribution to journalArticlepeer-review

51 Citations (Scopus)

Abstract

Purpose: To investigate whether pan-retinal photocoagulation (PRP) affects vitreous levels of cytokines and macular thickening in patients with high-risk proliferative diabetic retinopathy (PDR). Methods: Fourteen patients with bilateral high-risk PDR-which requires pars plana vitrectomy (PPV)-but without a history of retinal photocoagulation participated in this study. Before PPV, one eye received PRP, and the other eye did not. The concentrations of cytokines of vascular endothelial growth factor (VEGF), stromal derived factor-1 (SDF-1), interleukin-6 (IL-6) and regulated upon activation, normal T-cell expressed and secreted (RANTES) were measured in each vitreous sample obtained at PPV. Macular thickness obtained by optical coherence tomography was also monitored during clinical course. Results: After the PRP, macular thickness in PRP-pretreated eye showed temporal increase. Vitreous levels of IL-6 and RANTES in PRP pre-treated eye were significantly higher than levels in control eyes (p = 0.013, p = 0.033). Although macular thickness in control was correlated to vitreous levels of VEGF and IL-6 (p = 0.022, p = 0.003), that in PRP-pretreated eye was closely correlated to IL-6 and RANTES (p = 0.002, p = 0.011). After the PPV, macular thickness in both eye groups improved, and there was no significant difference between both eye groups 3 months after the PPV. Conclusions: In patients with high-risk PDR, PRP cause temporal worsening of macular edema linked with pro-inflammatory cytokines of IL-6 and RANTES, but not with VEGF and SDF-1. Thus, PRP-induced macular edema was caused by inflammation, while visual prognosis after PPV was not influenced by pretreatment of PRP.

Original languageEnglish
Pages (from-to)1617-1624
Number of pages8
JournalGraefe's Archive for Clinical and Experimental Ophthalmology
Volume247
Issue number12
DOIs
Publication statusPublished - 2009 Dec

Keywords

  • Cytokines
  • Diabetic retinopathy
  • Macular edema
  • Retinal photocoagulation

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

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