Pancreatic cancer cells activate CCL5 expression in mesenchymal stromal cells through the insulin-like growth factor-I pathway

Hideki Makinoshima, Mari Dezawa

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Mesenchymal stromal cells (MSCs) have a critical role in cancer progression and metastasis. Despite extensive studies of the physiological responses in cancer cells, the molecular mechanisms regulating gene expression in MSCs by cancer cells remain undefined. Here we demonstrate that CC chemokine ligand 5 (CCL5) expression was increased in MSCs co-cultured with pancreatic cancer cells (PCCs), and this activation was dependent on extracellular insulin-like growth factor (IGF-I). Moreover, CCL5 induction in MSCs was required for the activation of IGF-I pathway in PCCs. These results reveal a link between the IGF-I pathway in PCCs and CCL5 pathway in MSCs through the interaction of those cells.

Original languageEnglish
Pages (from-to)3697-3703
Number of pages7
JournalFEBS Letters
Volume583
Issue number22
DOIs
Publication statusPublished - 2009 Nov 19

Keywords

  • CC chemokine ligand 5
  • Gene expression
  • Insulin-like growth factor
  • Mesenchymal stromal cell
  • Pancreatic cancer cell
  • Tumor microenvironment

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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