Pancreatic acinar cell carcinoma with multiple liver metastases effectively treated by S-1 chemotherapy

Naoki Yoshida, Atsushi Kanno, Atsushi Masamune, Tatsuhide Nabeshima, Seiji Hongo, Shin Miura, Tetsuya Takikawa, Shin Hamada, Kazuhiro Kikuta, Kiyoshi Kume, Masamichi Ueno, Tooru Shimosegawa

Research output: Contribution to journalArticlepeer-review

Abstract

A 79-year-old woman was referred for pancreatic tail cancer with multiple liver metastases. The pancreatic tail tumor was diagnosed as acinar cell carcinoma (ACC) histologically by endoscopic ultrasound-guided fine-needle aspiration. Because of multiple liver metastases, S-1 chemotherapy was administered, resulting in a partial response to chemotherapy one year later. After approximately three years, liver atrophy and esophageal varices developed. We suspected S-1 as the cause of the liver cirrhosis. S-1 cessation minimized ascites and improved the esophageal varices. Although S-1 can potentially treat ACC, we should be watchful for liver cirrhosis caused by its long-term administration.

Original languageEnglish
Pages (from-to)3529-3535
Number of pages7
JournalInternal Medicine
Volume57
Issue number24
DOIs
Publication statusPublished - 2018

Keywords

  • Acinar
  • Chemotherapy
  • Liver cirrhosis

ASJC Scopus subject areas

  • Internal Medicine

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