Palladium(0)-catalyzed Mizoroki-Heck reaction and Rh(I)-catalyzed asymmetric hydrogenation of polymer-supported dehydroalanine system

Takayuki Doi, Nobuaki Fujimoto, Jun Watanabe, Takashi Takahashi

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)

Abstract

We have developed a practical route for the synthesis of peptides containing unnatural amino acids. Mizoroki-Heck reaction of polymer-supported dehydroalanine, followed by asymmetric hydrogenation was accomplished using Pd(0) and Rh(I)-DuPHOS catalysts, respectively, leading to 36 dipeptides containing phenylalanine derivatives with high stereocontrol.

Original languageEnglish
Pages (from-to)2161-2165
Number of pages5
JournalTetrahedron Letters
Volume44
Issue number10
DOIs
Publication statusPublished - 2003 Mar 3
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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