Palladium-catalyzed synthesis of N- and O-heterocycles starting from Enol phosphates

Haruhiko Fuwa

    Research output: Contribution to journalArticlepeer-review

    22 Citations (Scopus)

    Abstract

    In this Account, we describe our efforts in the development of new synthetic strategies for the construction of N- and O-heterocycles by exploiting palladium-catalyzed reactions using enol phosphates as an electrophilic component. 1 Introduction 2 Suzuki-Miyaura Coupling of Lactone-Derived Enol Phosphates: A Convergent Synthetic Strategy toward trans-Fused Polycyclic Ether Marine Metabolites 3 Domino Intramolecular Heck/Diels-Alder Reaction of Imide-Derived Enol Phosphates toward the Synthesis of Fused N-Heterocycles 4 Strategies for the Synthesis of 2-Substituted Indoles and Indolines via Suzuki-Miyaura Coupling of Imide-Derived Enol Phosphates 5 Palladium-Catalyzed Reduction of Enol Phosphates: Total Synthesis of (±)-Lennoxamine and (±)-Chilenine 6 Suzuki-Miyaura Coupling of an Acetate-Derived Enol Phosphate: Total Synthesis of (+)-Neopeltolide 7 Concluding Remarks.

    Original languageEnglish
    Article numberA57110ST
    Pages (from-to)6-29
    Number of pages24
    JournalSynlett
    Issue number1
    DOIs
    Publication statusPublished - 2011 Jan 1

    Keywords

    • cross-coupling
    • fused-ring systems
    • heterocycles
    • natural products
    • palladium
    • phosphates

    ASJC Scopus subject areas

    • Organic Chemistry

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