Palladium-catalyzed synthesis of 2-substituted benzothiazoles via a C-H functionalization/intramolecular C-S bond formation process

Kiyofumi Inamoto, Chisa Hasegawa, Kou Hiroya, Takayuki Doi

Research output: Contribution to journalArticlepeer-review

239 Citations (Scopus)

Abstract

(Chemical Equation Presented) Catalytic synthesis of 2-substituted benzothiazoles from thiobenzanilides was achieved in the presence of a palladium catalyst through C-H functionalization/C-S bond formation. This method features the use of a novel catalytic system consisting of 10 mol % of Pd(II), 50 mol % of Cu(I), and 2 equiv of Bu4NBr that produced variously substituted benzothiazoles in high yields with good functional group tolerance.

Original languageEnglish
Pages (from-to)5147-5150
Number of pages4
JournalOrganic letters
Volume10
Issue number22
DOIs
Publication statusPublished - 2008 Dec 1

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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