Palladium-Catalyzed Reactions of Terminal Acetylenes and Olefins with Halo-1,3-azoles

Takao Sakamoto, Hideo Nagata, Yoshinori Kondo, Masafumi Shiraiwa, Hiroshi Yamanaka

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

The palladium-catalyzed reactions of 4-bromo- and 5-bromothiazoles, as well as 4-bromo- and 5-bromooxazoles with terminal acetylenes gave ethynyl derivatives in 43—89% yields, whereas the reactions of 2-bromothiazoles and iodo-N-methylimidazoles afforded the products in poor yields. The reaction of the halo-1,3-azoles with terminal olefins was also examined.

Original languageEnglish
Pages (from-to)823-828
Number of pages6
JournalChemical and Pharmaceutical Bulletin
Volume35
Issue number2
DOIs
Publication statusPublished - 1987 Jan 1

Keywords

  • bromooxazole
  • bromothiazole
  • ethenyl-N-methylimidazole
  • ethenyl-oxazole
  • ethenylthiazole
  • ethynyl-N-methylimidazole
  • ethynyloxazole
  • ethynylthiazole
  • iodo-N-methyl-imidazole
  • palladium-catalyzed reaction

ASJC Scopus subject areas

  • Chemistry(all)
  • Drug Discovery

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