Abstract
The palladium-catalyzed reactions of 4-bromo- and 5-bromothiazoles, as well as 4-bromo- and 5-bromooxazoles with terminal acetylenes gave ethynyl derivatives in 43—89% yields, whereas the reactions of 2-bromothiazoles and iodo-N-methylimidazoles afforded the products in poor yields. The reaction of the halo-1,3-azoles with terminal olefins was also examined.
Original language | English |
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Pages (from-to) | 823-828 |
Number of pages | 6 |
Journal | Chemical and Pharmaceutical Bulletin |
Volume | 35 |
Issue number | 2 |
DOIs | |
Publication status | Published - 1987 |
Keywords
- bromooxazole
- bromothiazole
- ethenyl-N-methylimidazole
- ethenyl-oxazole
- ethenylthiazole
- ethynyl-N-methylimidazole
- ethynyloxazole
- ethynylthiazole
- iodo-N-methyl-imidazole
- palladium-catalyzed reaction
ASJC Scopus subject areas
- Chemistry(all)
- Drug Discovery