Palladium-catalyzed inter- and intramolecular hydroamination of methylenecyclopropanes with amines

Itaru Nakamura, H. Itagaki, Y. Yamamoto

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)

Abstract

The inter- and intramolecular addition of nitrogen pronucleophiles to methylenecyclopropanes proceeds smoothly in the presence of palladium catalyst, giving the corresponding hydroamination products in good to excellent yields. The reaction proceeds mainly through cleavage of a distal bond of methylenecyclopropanes.

Original languageEnglish
Pages (from-to)1532-1540
Number of pages9
JournalChemistry of Heterocyclic Compounds
Volume37
Issue number12
DOIs
Publication statusPublished - 2001 Dec 1

Keywords

  • Azepane derivative
  • Hydroamination
  • Methylenecyclopropane
  • Nitrogen pronucleophile
  • Palladium catalyst

ASJC Scopus subject areas

  • Organic Chemistry

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