Palladium-catalyzed inter- and intramolecular hydroamination of methylenecyclopropanes with amines

Itaru Nakamura; H. Itagaki; Y. Yamamoto

doi:10.1023/A:1014513411239

Palladium-catalyzed inter- and intramolecular hydroamination of methylenecyclopropanes with amines

Itaru Nakamura, H. Itagaki, Y. Yamamoto

SCI - Research and Analytical Center for Giant Molecules

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

The inter- and intramolecular addition of nitrogen pronucleophiles to methylenecyclopropanes proceeds smoothly in the presence of palladium catalyst, giving the corresponding hydroamination products in good to excellent yields. The reaction proceeds mainly through cleavage of a distal bond of methylenecyclopropanes.

Original language	English
Pages (from-to)	1532-1540
Number of pages	9
Journal	Chemistry of Heterocyclic Compounds
Volume	37
Issue number	12
DOIs	https://doi.org/10.1023/A:1014513411239
Publication status	Published - 2001 Dec 1

Keywords

Azepane derivative
Hydroamination
Methylenecyclopropane
Nitrogen pronucleophile
Palladium catalyst

ASJC Scopus subject areas

Organic Chemistry

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title = "Palladium-catalyzed inter- and intramolecular hydroamination of methylenecyclopropanes with amines",

abstract = "The inter- and intramolecular addition of nitrogen pronucleophiles to methylenecyclopropanes proceeds smoothly in the presence of palladium catalyst, giving the corresponding hydroamination products in good to excellent yields. The reaction proceeds mainly through cleavage of a distal bond of methylenecyclopropanes.",

keywords = "Azepane derivative, Hydroamination, Methylenecyclopropane, Nitrogen pronucleophile, Palladium catalyst",

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AU - Nakamura, Itaru

AU - Itagaki, H.

AU - Yamamoto, Y.

PY - 2001/12/1

Y1 - 2001/12/1

N2 - The inter- and intramolecular addition of nitrogen pronucleophiles to methylenecyclopropanes proceeds smoothly in the presence of palladium catalyst, giving the corresponding hydroamination products in good to excellent yields. The reaction proceeds mainly through cleavage of a distal bond of methylenecyclopropanes.

AB - The inter- and intramolecular addition of nitrogen pronucleophiles to methylenecyclopropanes proceeds smoothly in the presence of palladium catalyst, giving the corresponding hydroamination products in good to excellent yields. The reaction proceeds mainly through cleavage of a distal bond of methylenecyclopropanes.

KW - Azepane derivative

KW - Hydroamination

KW - Methylenecyclopropane

KW - Nitrogen pronucleophile

KW - Palladium catalyst

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