Palladium-catalyzed indole and benzofuran ring formation accompanying carbonylation

Yoshinori Kondo, Takao Sakamoto, Hiroshi Yamanaka

Research output: Contribution to journalArticlepeer-review

70 Citations (Scopus)


The reaction of 2-(1-hexynyl)aniline with carbon monoxide in methanol under basic conditions is promoted by the catalytic action of palladium dichloride to give methyl 2-butylindole-3-carboxylate. Similarly, the reaction of 2-(1-hexynyl)-phenol under the same conditions gives methyl 2-butylbenzofuran-3-carboxylate. The carbonylative cyclization mentioned above is successful with the corresponding 2-phenylethynyl derivatives of aniline and phenol.

Original languageEnglish
Pages (from-to)1013-1016
Number of pages4
Issue number6
Publication statusPublished - 1989 Jun 1

ASJC Scopus subject areas

  • Analytical Chemistry
  • Pharmacology
  • Organic Chemistry


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