Palladium-Catalyzed Highly Chemoselective Intramolecular C-H Aminocarbonylation of Phenethylamines to Six-Membered Benzolactams

Hiroshi Taneda, Kiyofumi Inamoto, Yoshinori Kondo

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

A palladium-catalyzed highly selective intramolecular C-H aminocarbonylation of Br-functionalized phenethylamines in the presence of CO was achieved while leaving the C-Br bond unreacted to afford six-membered benzolactams with good to high yields. The remaining C-Br group in the cyclized product was successfully used as a reactive center for further functionalization through various palladium-catalyzed coupling reactions.

Original languageEnglish
Pages (from-to)2712-2715
Number of pages4
JournalOrganic letters
Volume18
Issue number11
DOIs
Publication statusPublished - 2016 Jun 3

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

Fingerprint Dive into the research topics of 'Palladium-Catalyzed Highly Chemoselective Intramolecular C-H Aminocarbonylation of Phenethylamines to Six-Membered Benzolactams'. Together they form a unique fingerprint.

  • Cite this