Abstract
A palladium-catalyzed highly selective intramolecular C-H aminocarbonylation of Br-functionalized phenethylamines in the presence of CO was achieved while leaving the C-Br bond unreacted to afford six-membered benzolactams with good to high yields. The remaining C-Br group in the cyclized product was successfully used as a reactive center for further functionalization through various palladium-catalyzed coupling reactions.
| Original language | English |
|---|---|
| Pages (from-to) | 2712-2715 |
| Number of pages | 4 |
| Journal | Organic letters |
| Volume | 18 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - 2016 Jun 3 |
ASJC Scopus subject areas
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry
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Taneda, H., Inamoto, K., & Kondo, Y. (2016). Palladium-Catalyzed Highly Chemoselective Intramolecular C-H Aminocarbonylation of Phenethylamines to Six-Membered Benzolactams. Organic letters, 18(11), 2712-2715. https://doi.org/10.1021/acs.orglett.6b01171