Palladium-Catalyzed Coupling Reaction of 3-Iodoindoles and 3-Iodobenzo[b]thiophene with Terminal Acetylenes

Takao Sakamoto, Tatsuo Nagano, Yoshinori Kondo, Hiroshi Yamanaka

Research output: Contribution to journalArticlepeer-review

53 Citations (Scopus)

Abstract

The palladium-catalyzed coupling reaction of 3-iodoindoles possessing an electron-withdrawing group at the 1- or 2-position with terminal acetylenes smoothly proceeded to yield 3-ethynylindoles. Similarly, the reaction of 3-iodobenzo[b]thiophene gave the expected products, but the reaction of 3-bromobenzo[b]furan provided resinous materials.

Original languageEnglish
Pages (from-to)2248-2252
Number of pages5
JournalChemical and Pharmaceutical Bulletin
Volume36
Issue number6
DOIs
Publication statusPublished - 1988 Jan 1

Keywords

  • 3-ethynylbenzo[b]thiophene
  • 3-ethynylindole
  • 3-iodobenzo[b]lthiophene
  • 3-iodoindole
  • palladium-catalyzed reaction
  • terminal acetylene

ASJC Scopus subject areas

  • Chemistry(all)
  • Drug Discovery

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