Palladium-catalyzed C-H cyclization in water: A milder route to 2-arylbenzothiazoles

Kiyofumi Inamoto, Kanako Nozawa, Yoshinori Kondo

Research output: Contribution to journalArticlepeer-review

26 Citations (Scopus)


Water was successfully employed as a reaction medium in palladium-catalyzed C-H cyclization of thiobenzanilides. Reactions efficiently proceeded under considerably mild conditions such as 40 °C in water, providing a more practical, greener method for the synthesis of 2-arylbenzothiazoles. For some substrates, the addition of an amphiphilic surfactant greatly enhanced the process. The method represents a rare example of palladium-catalyzed C-H functionalization processes performed in water.

Original languageEnglish
Pages (from-to)1678-1682
Number of pages5
Issue number11
Publication statusPublished - 2012


  • C-H functionalization
  • catalysis
  • heterocycles
  • palladium
  • water

ASJC Scopus subject areas

  • Organic Chemistry


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