Abstract
Water was successfully employed as a reaction medium in palladium-catalyzed C-H cyclization of thiobenzanilides. Reactions efficiently proceeded under considerably mild conditions such as 40 °C in water, providing a more practical, greener method for the synthesis of 2-arylbenzothiazoles. For some substrates, the addition of an amphiphilic surfactant greatly enhanced the process. The method represents a rare example of palladium-catalyzed C-H functionalization processes performed in water.
Original language | English |
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Pages (from-to) | 1678-1682 |
Number of pages | 5 |
Journal | Synlett |
Volume | 23 |
Issue number | 11 |
DOIs | |
Publication status | Published - 2012 |
Keywords
- C-H functionalization
- catalysis
- heterocycles
- palladium
- water
ASJC Scopus subject areas
- Organic Chemistry