Palladium-catalyzed C-H activation/intramolecular amination reaction: A new route to 3-aryl/alkylindazoles

Kiyofumi Inamoto, Tadataka Saito, Mika Katsuno, Takao Sakamoto, Kou Hiroya

Research output: Contribution to journalArticlepeer-review

269 Citations (Scopus)


A method for the catalytic C-H activation of hydrazone compounds followed by intramolecular amination is described. It requires the use of a catalytic amount of Pd(OAc)2 in the presence of Cu(OAc)2 and AgOCOCF3, which efficiently effects the cyclization to afford variously substituted indazoles. The reactions proceed under relatively mild conditions and thus tolerate a variety of functional groups, including alkoxycarbonyl and cyano groups and halogen atoms.

Original languageEnglish
Pages (from-to)2931-2934
Number of pages4
JournalOrganic letters
Issue number15
Publication statusPublished - 2007 Jul 19
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry


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