Palladium-catalyzed asymmetric addition of arylboronic acids to nitrostyrenes

Qun He, Fang Xie, Guanghong Fu, Mao Quan, Chaoren Shen, Guoqiang Yang, Ilya D. Gridnev, Wanbin Zhang

Research output: Contribution to journalArticlepeer-review

40 Citations (Scopus)


A palladium-catalyzed asymmetric addition of arylboronic acids to nitrostyrene is reported. The catalytic system employing iPr-IsoQuinox as a chiral ligand in MeOH solvent under an air atmosphere provides the chiral diarylsubstituted products in high yields with good enantioselectivities. A variety of functionalized nitrostyrenes can be used, and the method tolerates some variation in arylboronic acid scope. The stereochemical outcome can be explained using a stereochemical model.

Original languageEnglish
Pages (from-to)2250-2253
Number of pages4
JournalOrganic letters
Issue number9
Publication statusPublished - 2015 May 1

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry


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