Palladium-catalyzed aerobic oxidative cyclization of N-aryl imines: Indole synthesis from anilines and ketones

Ye Wei, Indubhusan Deb, Naohiko Yoshikai

Research output: Contribution to journalArticlepeer-review

261 Citations (Scopus)

Abstract

We report here an operationally simple, palladium-catalyzed cyclization reaction of N-aryl imines, affording indoles via the oxidative linkage of two C-H bonds under mild conditions using molecular oxygen as the sole oxidant. The process allows quick and atom-economical assembly of indole rings from inexpensive and readily available anilines and ketones and tolerates a broad range of functional groups.

Original languageEnglish
Pages (from-to)9098-9101
Number of pages4
JournalJournal of the American Chemical Society
Volume134
Issue number22
DOIs
Publication statusPublished - 2012 Jun 6
Externally publishedYes

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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