Palladium-catalyzed addition of alcohol pronucleophiles to alkylidenecyclopropanes

D. H. Camacho, I. Nakamura, S. Saito, Y. Yamamoto

Research output: Contribution to journalArticlepeer-review

101 Citations (Scopus)

Abstract

Palladium-catalyzed addition of alcohol pronucleophiles 1 to alkylidenecyclopropane derivatives afforded the corresponding allylic ethers 3 in excellent to moderate yields. Catalyst optimization indicated the Pd(PPh3)4-P(o-tolyl)3 combination as the best system among all catalysts tested. Intramolecular reaction also proceeded smoothly. A plausible mechanism for this catalytic reaction was proposed.

Original languageEnglish
Pages (from-to)270-275
Number of pages6
JournalJournal of Organic Chemistry
Volume66
Issue number1
DOIs
Publication statusPublished - 2001 Jan 12

ASJC Scopus subject areas

  • Organic Chemistry

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