TY - JOUR
T1 - Paired Ig-like receptors bind to bacteria and shape TLR-mediated cytokine production
AU - Nakayama, Masafumi
AU - Underhill, David M.
AU - Petersen, Timothy W.
AU - Li, Bin
AU - Kitamura, Toshio
AU - Takai, Toshiyuki
AU - Aderem, Alan
N1 - Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2007/4/1
Y1 - 2007/4/1
N2 - The innate immune system uses a wide variety of pattern recognition receptors including TLRs, scavenger receptors, and lectins to identify potential pathogens. A carefully regulated balance between activation and inhibition must be kept to avoid detrimental and inappropriate inflammatory responses. In this study, we identify murine-paired Ig-like receptor (PIR)-B, and its human orthologs Ig-like transcript 2 and Ig-like transcript 5 as novel receptors for Staphylococcus aureus. PIR-B contains four ITIM motifs and is thought to be an inhibitory receptor. Expression of these receptors enables NIH3T3 cells to bind S. aureus. In mouse bone marrow-derived macrophages, masking of PIR-B by anti-PIR mAb or genetic deletion of PIR-B shows significantly impaired recognition of S. aureus and enhanced TLR-mediated inflammatory responses to the bacteria. These data suggest a novel mechanism for innate immune regulation by paired Ig-Iike receptor family members.
AB - The innate immune system uses a wide variety of pattern recognition receptors including TLRs, scavenger receptors, and lectins to identify potential pathogens. A carefully regulated balance between activation and inhibition must be kept to avoid detrimental and inappropriate inflammatory responses. In this study, we identify murine-paired Ig-like receptor (PIR)-B, and its human orthologs Ig-like transcript 2 and Ig-like transcript 5 as novel receptors for Staphylococcus aureus. PIR-B contains four ITIM motifs and is thought to be an inhibitory receptor. Expression of these receptors enables NIH3T3 cells to bind S. aureus. In mouse bone marrow-derived macrophages, masking of PIR-B by anti-PIR mAb or genetic deletion of PIR-B shows significantly impaired recognition of S. aureus and enhanced TLR-mediated inflammatory responses to the bacteria. These data suggest a novel mechanism for innate immune regulation by paired Ig-Iike receptor family members.
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U2 - 10.4049/jimmunol.178.7.4250
DO - 10.4049/jimmunol.178.7.4250
M3 - Article
C2 - 17371981
AN - SCOPUS:33947678884
VL - 178
SP - 4250
EP - 4259
JO - Journal of Immunology
JF - Journal of Immunology
SN - 0022-1767
IS - 7
ER -