'Pain relief' learning in fruit flies

Ayse Yarali, Thomas Niewalda, Yi chun Chen, Hiromu Tanimoto, Stefan Duerrnagel, Bertram Gerber

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

We studied the behavioural consequences of 'traumatic', painful experiences. These consequences were fundamentally asymmetric. Fruit flies, Drosophila melanogaster, learned two kinds of prediction regarding a 'traumatic' experience. If an odour preceded an electric shock during training, it predicted shock, and flies subsequently avoided it. When the sequence of events during training was reversed, that is odour followed shock, the odour predicted relief from shock and flies approached it. We call this latter effect 'relief' learning and showed that, in terms of psychological mechanisms, it established genuinely associative conditioned approach behaviour. Parametric analyses showed that relief learning was reproducible across experimenters; it did not depend on the flies' gender and reached asymptotic levels after six training trials. Of five chosen odour-pairs, two supported relief learning at all concentrations tested; for one odour-pair, we observed optimal relief learning at an intermediate odour concentration; for two odour-pairs, relief learning could not be demonstrated. Furthermore, relief learning was maximal with relatively mild shocks, supporting stable retention for the first 2 h after training. Knowledge of these parametric features should aid uncovering relief learning in other experimental systems. In terms of psychological mechanism, context-shock pretraining had no effect on subsequent relief learning, suggesting that it is not mediated by context associations. These analyses may further our understanding of the psychological mechanisms underlying behavioural changes after traumatic experience. They facilitate research into the neurobiology of pain relief learning, enabling the implementation of truly bioinspired learning rules for technical devices.

Original languageEnglish
Pages (from-to)1173-1185
Number of pages13
JournalAnimal Behaviour
Volume76
Issue number4
DOIs
Publication statusPublished - 2008 Oct 1
Externally publishedYes

Keywords

  • Drosophila melanogaster
  • associative learning
  • fruit fly
  • olfaction
  • pain relief
  • parametric analyses

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Animal Science and Zoology

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    Yarali, A., Niewalda, T., Chen, Y. C., Tanimoto, H., Duerrnagel, S., & Gerber, B. (2008). 'Pain relief' learning in fruit flies. Animal Behaviour, 76(4), 1173-1185. https://doi.org/10.1016/j.anbehav.2008.05.025