PAF and PAF acetylhydrolase in the nervous system

Mitsuharu Hattori, Junken Aoki, Hiroyuki Arai, Keizo Inoue

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)


PAF acetylhydrolase is a key enzyme of PAF inactivation. Intracellular PAF acetylhydrolase isoform Ib is a heterotrimeric enzyme composed of α-, β- and γ-subunits. The β- and γ-subunits act as a catalytic unit and their amino acid sequences are homologous. The α-subunit is not essential for catalytic activity but is a product of the causative gene for Miller-Dicker lissencephaly, suggesting this subunit plays an important role in brain development.

Original languageEnglish
Pages (from-to)99-102
Number of pages4
JournalJournal of Lipid Mediators and Cell Signalling
Issue number1-3
Publication statusPublished - 1996 Sep
Externally publishedYes


  • Miller-Dicker lissencephaly
  • PAF acetylhydrolase
  • Zellweger syndrome
  • isoforms

ASJC Scopus subject areas

  • Immunology
  • Pharmacology


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