PAF and PAF acetylhydrolase in the nervous system

Mitsuharu Hattori, Junken Aoki, Hiroyuki Arai, Keizo Inoue

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

PAF acetylhydrolase is a key enzyme of PAF inactivation. Intracellular PAF acetylhydrolase isoform Ib is a heterotrimeric enzyme composed of α-, β- and γ-subunits. The β- and γ-subunits act as a catalytic unit and their amino acid sequences are homologous. The α-subunit is not essential for catalytic activity but is a product of the causative gene for Miller-Dicker lissencephaly, suggesting this subunit plays an important role in brain development.

Original languageEnglish
Pages (from-to)99-102
Number of pages4
JournalJournal of Lipid Mediators and Cell Signalling
Volume14
Issue number1-3
DOIs
Publication statusPublished - 1996 Sep
Externally publishedYes

Keywords

  • Miller-Dicker lissencephaly
  • PAF acetylhydrolase
  • Zellweger syndrome
  • isoforms

ASJC Scopus subject areas

  • Immunology
  • Pharmacology

Fingerprint Dive into the research topics of 'PAF and PAF acetylhydrolase in the nervous system'. Together they form a unique fingerprint.

  • Cite this