Paclitaxel and carboplatin in patients with completely or optimally resected carcinosarcoma of the uterus: A phase II trial by the Japanese uterine sarcoma group and the tohoku gynecologic cancer unit

Ai Otsuki, Yoh Watanabe, Hiroyuki Nomura, Masayuki Futagami, Yoshihito Yokoyama, Kiyosumi Shibata, Seiryu Kamoi, Atsushi Arakawa, Hiroshi Nishiyama, Takahiro Katsuta, Wataru Kudaka, Muneaki Shimada, Naoki Sato, Kouhei Kotera, Hidetaka Katabuchi, Nobuo Yaegashi

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Objective: This study aimed to evaluate the efficacy of paclitaxel and carboplatin in patients with completely or optimally resected uterine carcinosarcoma. Materials and Methods: We conducted a single-arm multicenter prospective phase II trial at 20 Japanese medical facilities. Eligible patients had histologically confirmed uterine carcinosarcoma without prior chemotherapy or radiotherapy. Patients received 6 courses of 175 mg/m2 paclitaxel over 3 hours, followed by a 30-minute intravenous administration of carboplatin at an area under the serum concentration-time curve of 6. Results: A total of 51 patients were enrolled in this study, 48 of whom underwent complete resection and 3 of whom underwent optimal resection. At 2 years, the progression-free survival and overall survival rates were 78.2% (95% confidence interval [CI], 64.1%Y87.3%) and 87.9% (95% CI, 75.1%Y94.4%), respectively. At 4 years, these rates were 67.9% (95% CI, 53.0%Y79.0%) and 76.0% (95% CI, 60.5%Y86.1%), respectively. Although 15 patients showed disease recurrence during the follow-up period (median, 47.8 months; range, 2.1Y72.8 months), a total of 40 (78.4%) patients completed the 6 courses of treatment that had been planned. Conclusions: The combination of paclitaxel and carboplatin was a feasible and effective postoperative adjuvant therapy for patients with completely or optimally resected uterine carcinosarcoma.

Original languageEnglish
Pages (from-to)92-97
Number of pages6
JournalInternational Journal of Gynecological Cancer
Volume25
Issue number1
DOIs
Publication statusPublished - 2015 Jan 1

Keywords

  • Adjuvant chemotherapy
  • Phase II trial
  • Uterine carcinosarcoma

ASJC Scopus subject areas

  • Oncology
  • Obstetrics and Gynaecology

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