TY - JOUR
T1 - P2-purinergic receptor antagonists reduce the minimum alveolar concentration of inhaled volatile anesthetics
AU - Masaki, Eiji
AU - Ebisawa, Takanori
AU - Kondo, Ichiro
AU - Hayashida, Keiko
AU - Matsumoto, Yasunori
AU - Kawamura, Masahiro
N1 - Funding Information:
This work was supported in part by Grant-in-Aid for Scientific Research (C) from the Ministry of Education, Science, Sports and Culture of Japan, and the Japan Health Science Foundation. The authors thank Dr Ashraf Ahmed for his expert manuscript preparation.
PY - 2000/5/5
Y1 - 2000/5/5
N2 - In the central nervous system (CNS), adenosine triphosphate (ATP) is reported to serve as a fast excitatory neurotransmitter via P2X receptor. To examine possible involvement of inhibition of ATP signal-transmission in anesthetic mechanism, the effect of intracerebroventricular (ICV) administration of P2 receptor antagonists on the minimum alveolar concentration (MAC) of sevoflurane and isoflurane was studied in rat. ICV administration of P2 receptor antagonists, suramin and pyridoxal-phosphate-6- azophenyl-2',4'-disulphonic acid (PPADS), significantly reduced MAC of both anesthetics. The reduction of the MAC by both suramin and PPADS was dose- dependent and reached plateau at 150 μg/rat. These results suggest that the inhibition of ATP-signal transmission may be involved in analgesic or anesthetic effect in brain. (C) 2000 Elsevier Science B.V.
AB - In the central nervous system (CNS), adenosine triphosphate (ATP) is reported to serve as a fast excitatory neurotransmitter via P2X receptor. To examine possible involvement of inhibition of ATP signal-transmission in anesthetic mechanism, the effect of intracerebroventricular (ICV) administration of P2 receptor antagonists on the minimum alveolar concentration (MAC) of sevoflurane and isoflurane was studied in rat. ICV administration of P2 receptor antagonists, suramin and pyridoxal-phosphate-6- azophenyl-2',4'-disulphonic acid (PPADS), significantly reduced MAC of both anesthetics. The reduction of the MAC by both suramin and PPADS was dose- dependent and reached plateau at 150 μg/rat. These results suggest that the inhibition of ATP-signal transmission may be involved in analgesic or anesthetic effect in brain. (C) 2000 Elsevier Science B.V.
KW - Adenosine triphosphate
KW - Anesthetic mechanisms
KW - Inhaled volatile anesthetics
KW - P2 receptor
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U2 - 10.1016/S0006-8993(00)02169-7
DO - 10.1016/S0006-8993(00)02169-7
M3 - Article
C2 - 10793195
AN - SCOPUS:0034607558
VL - 864
SP - 130
EP - 133
JO - Molecular Brain Research
JF - Molecular Brain Research
SN - 0006-8993
IS - 1
ER -