P2-purinergic receptor antagonists reduce the minimum alveolar concentration of inhaled volatile anesthetics

Eiji Masaki, Takanori Ebisawa, Ichiro Kondo, Keiko Hayashida, Yasunori Matsumoto, Masahiro Kawamura

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

In the central nervous system (CNS), adenosine triphosphate (ATP) is reported to serve as a fast excitatory neurotransmitter via P2X receptor. To examine possible involvement of inhibition of ATP signal-transmission in anesthetic mechanism, the effect of intracerebroventricular (ICV) administration of P2 receptor antagonists on the minimum alveolar concentration (MAC) of sevoflurane and isoflurane was studied in rat. ICV administration of P2 receptor antagonists, suramin and pyridoxal-phosphate-6- azophenyl-2',4'-disulphonic acid (PPADS), significantly reduced MAC of both anesthetics. The reduction of the MAC by both suramin and PPADS was dose- dependent and reached plateau at 150 μg/rat. These results suggest that the inhibition of ATP-signal transmission may be involved in analgesic or anesthetic effect in brain. (C) 2000 Elsevier Science B.V.

Original languageEnglish
Pages (from-to)130-133
Number of pages4
JournalBrain research
Volume864
Issue number1
DOIs
Publication statusPublished - 2000 May 5

Keywords

  • Adenosine triphosphate
  • Anesthetic mechanisms
  • Inhaled volatile anesthetics
  • P2 receptor

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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