Oxytocinergic circuit from paraventricular and supraoptic nuclei to arcuate POMC neurons in hypothalamus

Yuko Maejima, Kazuya Sakuma, Putra Santoso, Darambazar Gantulga, Kenichi Katsurada, Yoichi Ueta, Yuichi Hiraoka, Katsuhiko Nishimori, Shigeyasu Tanaka, Kenju Shimomura, Toshihiko Yada

Research output: Contribution to journalArticlepeer-review

58 Citations (Scopus)


Intracerebroventricular injection of oxytocin (Oxt), a neuropeptide produced in hypothalamic paraventricular (PVN) and supraoptic nuclei (SON), melanocortin-dependently suppresses feeding. However, the underlying neuronal pathway is unclear. This study aimed to determine whether Oxt regulates propiomelanocortin (POMC) neurons in the arcuate nucleus (ARC) of the hypothalamus. Intra-ARC injection of Oxt decreased food intake. Oxt increased cytosolic Ca2+ in POMC neurons isolated from ARC. ARC POMC neurons expressed Oxt receptors and were contacted by Oxt terminals. Retrograde tracer study revealed the projection of PVN and SON Oxt neurons to ARC. These results demonstrate the novel oxytocinergic signaling from PVN/SON to ARC POMC, possibly regulating feeding.

Original languageEnglish
Pages (from-to)4404-4412
Number of pages9
JournalFEBS Letters
Issue number23
Publication statusPublished - 2014 Nov 28
Externally publishedYes


  • Arcuate nucleus
  • Feeding
  • Obesity
  • Oxytocin
  • Proopiomelanocortin

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology


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