Oxytocin receptor is regulated by Peg3

Wesley D. Frey, Kaustubh Sharma, Terri L. Cain, Katsuhiko Nishimori, Ryoichi Teruyama, Joomyeong Kim

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


Mouse Peg3 encodes a DNA-binding protein involved in the milk letdown process. In the current study, we tested whether PEG3 controls the expression of the oxytocin receptor gene. According to the results, PEG3 directly binds to a genomic region within the 3rd exon of Oxtr, which contains a DNA-binding motif for PEG3. In nursing female mice, removal of PEG3 resulted in the increased expression of Oxtr in mammary epithelial cells and also in the hypothalamus. This suggests a repressor role of PEG3 in the expression of Oxtr in these tissues. Overall, this study suggests that Peg3 may function as a direct transcriptional regulator for Oxtr expression that acts to moderate the milk letdown process.

Original languageEnglish
Article numbere0202476
JournalPloS one
Issue number8
Publication statusPublished - 2018 Aug

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

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